Ticker · CUSIP 03770N101

APGE

APOGEE THERAPEUTICS INC

Healthcare·Biotechnology

···Share

Holders (tracked)

Combined shares

7,119,958

Combined value

$537.42M

Last close

$92.20

Quarter

2025Q4

Price is +22.2% vs the avg quarter-end implied price across tracked holders.

Price · 1Y$92.20+59.09 (+178.47%)H $92.20 · L $32.85 · Avg Vol 854K

Insider sellPosition opened

Tracked holders · last 8 quarters

+1 vs previous quarter over the last 8.

SEC event timeline

18 events

HENDERSON MICHAEL THOMAS · Chief Executive Officer
2026-04-08
Sold $1.47M @ $82.48
Insider sell
HENDERSON MICHAEL THOMAS · Chief Executive Officer
2026-04-08
Sold $166.5K @ $83.26
Insider sell
HENDERSON MICHAEL THOMAS · Chief Executive Officer
2026-04-08
Sold $17.0K @ $85.00
Insider sell
Ken Griffin (Citadel Advisors) trimmed2026-02-17
−402,263 shares · 2025Q4
Position
D.E. Shaw & Co. trimmed2026-02-17
−37,320 shares · 2025Q4
Position
Two Sigma Investments trimmed2026-02-17
−17,134 shares · 2025Q4
Position
Izzy Englander (Millennium Mgmt) trimmed2026-02-17
−289,736 shares · 2025Q4
Position
T. Rowe Price added2026-02-17
+486,606 shares · 2025Q4
Position
Paul Tudor Jones (Tudor Investment) opened position2026-02-17
+30,039 shares · 2025Q4
Position
Wellington Management added2026-02-17
+22,884 shares · 2025Q4
Position
T. Rowe Price trimmed2025-11-14
−10,315 shares · 2025Q3
Position
Steve Cohen (Point72) exited2025-11-14
−1,230,377 shares · 2025Q3
Position
Two Sigma Investments added2025-11-14
+6,681 shares · 2025Q3
Position
D.E. Shaw & Co. trimmed2025-11-14
−93,958 shares · 2025Q3
Position
Wellington Management added2025-11-14
+917,991 shares · 2025Q3
Position
Izzy Englander (Millennium Mgmt) added2025-11-14
+185,330 shares · 2025Q3
Position
Renaissance Technologies exited2025-11-13
−41,100 shares · 2025Q3
Position
Norges Bank (Norway SWF) exited2025-11-12
−12,121 shares · 2024Q3
Position

Insider activity

Last 30 days

Net (open-market)

−$1.65M

Buys

0 · $0

Sells

3 · $1.65M

Unique insiders

Date	Insider	Code	Shares	Price	Value
04-08	HENDERSON MICHAEL THOMAS Chief Executive Officer · Officer, Director	S	17,800	$82.48	$1.47M
04-08	HENDERSON MICHAEL THOMAS Chief Executive Officer · Officer, Director	S	2,000	$83.26	$166.5K
04-08	HENDERSON MICHAEL THOMAS Chief Executive Officer · Officer, Director	S	200	$85.00	$17.0K

View full insider history for APGE →

Follow-the-investor returns

If you'd copied each holder of APGE…

Cost basis inferred from each manager's quarter-over-quarter position changes. Sorted by % return on the position they're still holding.

Investor	First in	Cost basis	Return	Position value today
Wellington Management	2023Q3	$41.40	+122.7%	$437.6M
Izzy Englander (Millennium Mgmt)	2023Q4	$41.88	+120.1%	$13.0M
D.E. Shaw & Co.	2024Q2	$43.25	+113.2%	$5.8M
Two Sigma Investments	2023Q4	$44.21	+108.6%	$9.7M
Paul Tudor Jones (Tudor Investment)	2023Q3	$52.91	+74.3%	$2.8M
T. Rowe Price	2023Q3	$53.81	+71.4%	$114.1M
Ken Griffin (Citadel Advisors)	2023Q3	$74.82	+23.2%	$1.5M
Ken Griffin (Citadel Advisors)	2023Q3	$74.82	+23.2%	$1.5M
Ken Griffin (Citadel Advisors)	2023Q3	$74.82	+23.2%	$1.5M

Who moved on this name in 2025Q4

Position changes reported for the latest quarter, grouped by direction.

New positions1

Paul Tudor Jones (Tudor Investment)
+30,039
$2.3M

Added to2

Wellington Management
+22,884
$1.7M
T. Rowe Price
+486,606
$37K

Trimmed4

Ken Griffin (Citadel Advisors)
−402,263
$30.4M
Izzy Englander (Millennium Mgmt)
−289,736
$21.9M
D.E. Shaw & Co.
−37,320
$2.8M
Two Sigma Investments
−17,134
$1.3M

Exited0

—

Institutional ownership over time

Distinct super-investors holding this ticker · combined dollar value, by quarter.

Quarter	Holders	Shares	Combined value	Δ holders
2023Q3	6	4,492,825	$94.9M	—
2023Q4	6	3,186,163	$89.0M	—
2024Q1	11	7,064,346	$469.4M	+5
2024Q2	13	8,084,042	$318.1M	+2
2024Q3	8	6,627,528	$389.3M	-5
2024Q4	9	1,845,585	$83.6M	+1
2025Q1	9	7,315,420	$273.3M	—
2025Q2	10	6,910,645	$300.1M	+1
2025Q3	8	7,324,882	$291.0M	-2
2025Q4	9	7,119,958	$537.4M	+1

Who owns APGE

9 super-investors · 2025Q4

Tracked stake

7.12M

Combined value

$537M

% of shares outstanding

—

shares-out unknown

Quarter action mix

New1Added2Trim6

#	Manager	Shares	Value	% of book	Last action
1	Wellington Management	4.75M	$358M	0.1%	Added+22.9K
2	T. Rowe Price	1.24M	$93M	0.0%	Added+486.6K
3	Ken Griffin Citadel Advisors	767.0K	$58M	0.0%	Trim−402.3K
4	Izzy Englander Millennium Mgmt	140.7K	$11M	0.0%	Trim−289.7K
5	Two Sigma Investments	105.2K	$8M	0.0%	Trim−17.1K
6	D.E. Shaw & Co.	63.3K	$5M	0.0%	Trim−37.3K
7	Paul Tudor Jones Tudor Investment	30.0K	$2M	0.0%	New+30.0K
8	Ken Griffin Citadel Advisors	15.8K	$1M	0.0%	Trim−402.3K
9	Ken Griffin Citadel Advisors	14.2K	$1M	0.0%	Trim−402.3K

Recent moves

20 transactions

TRIMTwo Sigma Investments
−17,134 · 2025Q4
ADDWellington Management
+22,884 · 2025Q4
ADDT. Rowe Price
+486,606 · 2025Q4
TRIMD.E. Shaw & Co.
−37,320 · 2025Q4
TRIMKen Griffin (Citadel Advisors)
−402,263 · 2025Q4
TRIMIzzy Englander (Millennium Mgmt)
−289,736 · 2025Q4
NEWPaul Tudor Jones (Tudor Investment)
+30,039 · 2025Q4
ADDTwo Sigma Investments
+6,681 · 2025Q3
ADDIzzy Englander (Millennium Mgmt)
+185,330 · 2025Q3
TRIMD.E. Shaw & Co.
−93,958 · 2025Q3
ADDWellington Management
+917,991 · 2025Q3
TRIMT. Rowe Price
−10,315 · 2025Q3
SOLDSteve Cohen (Point72)
−1,230,377 · 2025Q3
SOLDRenaissance Technologies
−41,100 · 2025Q3
SOLDNorges Bank (Norway SWF)
−12,121 · 2024Q3
TRIMTwo Sigma Investments
−136,441 · 2025Q2
TRIMT. Rowe Price
−61,006 · 2025Q2
TRIMIzzy Englander (Millennium Mgmt)
−15,202 · 2025Q2
ADDD.E. Shaw & Co.
+185,752 · 2025Q2
ADDSteve Cohen (Point72)
+837,889 · 2025Q2

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